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Step 2: Provider Review and Prescription Licensed healthcare providers through OpenLoop Health review each submission and make independent prescribing decisions

PlexusDx coordinates these monitoring touchpoints with your rheumatologist

The Rebound-Risk Estimator is a feature the brand describes as an "educational estimate of post-medication rebound risk based on the habits and signals you log." The brand explicitly labels it as "behavioral nudges, not medical advice." Weight regain after GLP-1 discontinuation is a documented concern in published research - a 2025 systematic review and meta-analysis published in eClinicalMedicine confirmed that weight, HbA1c, and blood pressure consistently rebound after cessation

The long-term safety profile is the more relevant question for maintenance therapy